The Laboratory of
Evolutionary Neurobiology
Leah Krubitzer pyr UC Davis
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Research Papers (1999-2014)

For a complete list of Dr. Krubitzer's publications, see her CV.

Dooley JC, Franca JG, Seelke AMH, Cooke DF and Krubitzer LA (2015) Evolution of mammalian sensorimotor cortex: thalamic projections to parietal cortical areas in Monodelphis domestica. Front Neuroanat. 8:163.

Cooke DF, Goldring AB, Baldwin MKL, Recanzone GH, Chen A, Pan T, Simon SI, and Krubitzer L (2014) Reversible deactivation of higher order posterior parietal areas I: Alternations of receptive field characteristics in early stages of neocortical processing.  J Neurophysiol. 112: 2529-2544. PMCID: PMC4233270

Goldring AB, Cooke DF, Baldwin MKL, Recanzone GH, Gordon AG, Pan T, Simon SI, and Krubitzer L (2014) Reversible deactivation of higher order posterior parietal areas II: Alterations in response properties of neurons in areas 1 and 2. J Neurophsiol. 112: 2545-2560. PMCID: PMC4233279.

Seelke AMH, Dooley JC, and Krubitzer LA (2014) Photic preferences of the short-tailed opossum (Monodelphis domestica). Neuroscience. 269:273-280. PMCID: PMC4020983

Seelke AM, Dooley JC, and Krubitzer L (2014) The cellular composition of the marsupial neocortex. J Comp Neurol. 522:2286-2298. PMCID: PMC4090354

Dooley JC, Franca JG, Seelke AM, Cooke DF, Krubitzer LA (2013) A Connection to the Past: Monodelphis domestica Provides Insight Into the Organization and Connectivity of the Brains of Early Mammals. J Comp Neurol; 521:3877-3897. PMCID: PMC3959876

Seelke AM, Dooley JC, and Krubitzer LA (2013) Differential changes in the cellular composition of the developing marsupial brain. J Comp Neurol. 521:2602-2620. PMCID: PMC3934569

Dooley JC, Nguyen HM, Seelke AM, and Krubitzer L (2012) Visual acuity in the short-tailed opossum (Monodelphis domestica). Neuroscience. 223:124-130. PMCID: PMC3708803

Seekle AM, Dooley JC, and Krubitzer LA (2012) The emergence of somatotopic maps of the body in S1 in rats: the correspondence between functional and anatomical representation. PLoS One; 7(2): e32322. PMCID: PMC3290658

Cooke DF, Goldring AB, Yamayoshi I, Tsourkas P, Recanozone GH, Tiriac A, Pan T, Simon SI, and Krubitzer, L (2012). Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates. J Neurophysiol. 107:3543-3548. PMCID: PMC3378414

Seelke AM, Padberg JJ, Disbrow E, Purnell SM, Recanzone G, and Krubitzer L (2012) Topographic maps within Brodmann’s area 5 of macaque monkeys. Cereb Cortex 22:1834-1850. PMCID: PMC3388892

Campi KL, Collins CE, Todd WD, Kaas J, and Krubitzer L (2011) Comparison of Area 17 cellular composition in laboratory and wild-caught rats including diurnal and nocturnal species. Brain, Behav Evol. 77:116-130. PMCID: PMC3094678

Cooke DF, Padberg J, Zahner T, and Krubitzer L (2012) The functional organization and cortical connections of motor cortex in squirrels.Cereb Cortex. 22:1959-1978. PMCID: PMC3412438

Wang WZ, Oeschger FM, Montiel JF, García-Moreno F, Hoerder-Suabedissen A, Krubitzer L, Ek CJ, Saunders NR, Reim K, Villalón A, and Molnár Z (2011) Comparative aspects of subplate zone studied with gene expression in sauropsids and mammals. Cereb Cortex. 21:2187-2203. PMID: 21368089

Evans KD, Hewett TA, Clayton CJ, Krubitzer LA, and Griffey SM. (2010) Normal Organ Weights, Serum Chemistry, Hematology, and Cecal and Nasopharyngeal Bacterial Cultures in the Gray Short-Tailed Opossum (Monodelphis domestica). J Am Assoc Lab Anim Sci. 49:401-6. PMCID: PMC2919177

Padberg J, Recanzone G, Engle J, Cooke D, Goldring A, and Krubitzer, L (2010) Lesions in posterior parietal area 5 result in rapid behavioral and cortical plasticity. J Neurosci. 30:12918-12935. PMCID: PMC3432266

Campi KL and Krubitzer L (2010) Comparative studies of diurnal and nocturnal rodents: differences in lifestyle result in alterations in cortical field size and number. J Comp Neurol. 518:4491-4512. PMCID: PMC3432265

Zumer JM, Nagarajan SS, Krubitzer LA, Zhu Z, Turner RS, and Disbrow EA (2010) MEG in the macaque monkey and human: distinguishing cortical fields in space and time. Brain Res. 1345:110-124. PMCID: PMC2899153

Cheung AF, Kondo S, Abdel-Mannan O, Chodroff RA, Sirey TM, Bluy LE, Webber N, Karlen SJ, Krubitzer L, Stolp HB, Saunders NR, and Molnár Z (2010) The subventricular zone is the developmental milestone of a 6-layered neocortex: Comparisons in methatherian and eutherian mammals. Cereb Cortex 20:1071-1081. PMID: 19726493

Campi KL, Bales KL, Grunewald R, and Krubitzer, L (2010) Connections of Auditory Cortex in the Prairie Vole (Microtus ochrogaster): Evidence for multisensory processing in primary sensory areas. Cereb Cortex 20:89-108. PMCID: PMC2792189

Larsen DD, Luu JD, Burns ME, and Krubitzer L (2009) What are the effects of severe visual impairment on the cortical organization and connectivity of primary visual cortex? Front Neuroanat. 3:30. PMCID: PMC2802552

Hinkley LB, Krubitzer LA, Padberg J, and Disbrow EA (2009) Visual-manual exploration and posterior parietal cortex in humans. J Neurophysiol 102:3433-3446. PMCID: PMC2804435

Padberg J, Cerkevich C, Engle J, Rajan AT, Recanzone G, Kaas J, and Krubitzer L (2009) Thalamocortical connections of parietal somatosensory cortical fields in macaque monkeys are highly divergent and convergent. Cereb Cortex 19:2038-2064. PMCID: PMC2722424

Zhu Z, Zumer JM, Lowenthal ME, Padberg J, Recanzone GH, Krubitzer LA, Nagarajan SS, and Disbrow EA (2009) The relationship between magnetic and electrophysiological signals responses to complex tactile stimuli. BMC Neurosci. 10:4. PMCID: PMC2652466

Karlen SJ and Krubitzer L (2009) Effects of bilateral enucleation on the size of visual and non-visual areas of the brain. Cereb Cortex 19:1360-1371. PMCID: PMC2677651

Padberg J, Franc JG, Cooke DF, Soares JG, Rosa MG, Fiorani M Jr, Gattass R, Krubitzer L (2007) Parallel evolution of cortical areas involved in skilled hand use. J Neurosci. 27:10106-10115. PMID: 17881517

Campi KL, Karlen SJ, Bales KL, and Krubitzer L (2007) Organization of sensory neocortex in prairie voles (Microtus ochrogaster). J Comp Neurol. 502:414-426. PMID: 17366609

Hinkley L, Krubitzer L, Nagarajan SS, and Disbrow EA (2007) Integration of tactile and motor inputs in the second somatosensory and parietal rostral ventral areas of the human Sylvian fissure. J Neurophysiol. 97:1288-1297

Karlen SJ and Krubitzer L (2006) Phenotypic variability is the cornerstone of evolution: Variability in cortical field size within a species. J Comp Neurol. 499:990-999. PMID: 17072834

Karlen SJ, Kahn DM, and Krubitzer L (2006) Early blindness results in abnormal corticocortical and thalamocortical connections. Neuroscience. 142:843-858. PMID: 16934941

Padberg J and Krubitzer L (2006) Thalamocortical connections of anterior and posterior parietal cortical areas in New World titi monkeys. J Comp Neurol. 497:416-435. PMID: 16736469

Hunt DL, Yamoah EN, and Krubitzer L (2006) Multisensory plasticity in congenitally deaf mice: How are cortical areas functionally specified? Neuroscience. 139:1507-1524. PMID: 16529873

Hunt DL, King B, Kahn DM, Yamoah EN, Shull GE, and Krubitzer L (2005) Aberrant retinal projections in congenitally deaf mice: How are phenotypic characteristics specified in development and evolution. Anat Rec A Discov Mol Cell Evol Biol. 287:1051-1066. PMID: 16200647

Padberg, J, Disbrow, E, and Krubitzer, L (2005) The organization and connections of anterior and posterior parietal cortex in Titi monkeys:  Do New World Monkeys have an area 2? Cereb Cortex. 15:1938-1963. PMID: 15758196

Krubitzer L, Huffman KJ, Disbrow E, and Recanzone G (2004) The organization of area 3a in macaque monkeys. J Comp Neurol. 471:97-111. PMID: 14983479

Disbrow E, Litinas E, Recanzone GH, Padberg J, and Krubitzer L (2003) Cortical connections of the parietal ventral area and the second somatosensory area in macaque monkeys. J Comp Neurol. 462:382-399. PMID: 12811808

Kahn DM and Krubitzer L (2002) Massive cross-modal cortical plasticity and the emergence of a new cortical field in developmentally blind mammals. Proc Natl Acad Sci U S A. 99:11429-11434. PMCID: PMC123273

Disbrow E, Litinas E, Recanzone GH, Slutsky D, and Krubitzer LA (2002) Thalamocortical connections of the parietal ventral area (PV) and the second somatosensory area (S2) in macaque monkeys. Thalamus Relat Syst. 1:289-302

Kahn DM and Krubitzer L (2002) Retinofugal projections in the short-tailed opossum (Monodelphis domestica). J Comp Neurol. 447:114-127. PMID: 11977115

Huffman KJ and Krubitzer L (2001) Area 3a: Topographic organization and connections in marmoset monkeys. Cereb Cortex. 11:849-867. PMID: 11532890

Huffman KJ and Krubitzer L (2001) Thalamo-cortical connections of areas 3a and M1 in marmoset monkeys. J Comp Neurol. 435:291-310. PMID: 11406813

Disbrow E, Roberts T, Poeppel D, and Krubitzer L (2001) Evidence for interhemispheric processing of inputs from the hands in the human second somatosensory and parietal ventral areas. J Neurophsiol. 85:2236-2244. PMID: 11353038

Kahn DM, Huffman KJ, and Krubitzer L (2000) Organization and connections of V1 in Monodelphis domestica. J Comp Neurol. 428:337-354. PMID: 11064371

Disbrow EA, Slutsky DA, Roberts TP, and Krubitzer LA (2000) Functional MRI at 1.5 tesla: A comparison of the blood oxygenation level dependent signal and electrophysiology. Proc Natl Acad Sci U S A. 97:9718-9723. PMCID: PMC16931

Slutsky DA, Manger PR, and Krubitzer L (2000) Multiple somatosensory areas in the anterior parietal cortex of the California ground squirrel (Spermophilus beecheyii). J Comp Neurol. 416:521-539. PMID: 10660882

Disbrow E, Krubitzer L, and Roberts T (2000) The somatotopic organization of the lateral sulcus areas in Homo Sapiens: Evidence for SII and PV. J Comp Neurol. 418:1-21. PMID: 10701752

Huffman KJ, Molnár Z, Van Dellen A, Kahn D, Blakemore C, and Krubitzer L (1999) Formation of cortical fields on a reduced cortical sheet. J Neurosci. 19:9939-9952. PMID: 10559402

Disbrow E, Roberts T, Slutsky D, and Krubitzer L (1999) The use of fMRI for determining the topographic organization of cortical fields in human and nonhuman primates. Brain Res. 829:167-173. PMID: 10350543

Rosa MGP, Krubitzer LA, Molnar Z, and Nelson JE (1999) Organization of visual cortex in the northern quoll, Dasyurus hallucautus: Evidence for a homologue of the second visual area in marsupials. Eur J Neurosci. 11:907-915. PMID: 10103084

Huffman KJ, Nelson J, Clarey J, and Krubitzer L (1999) Neocortical organization in four species of marsupials: Neural correlates of morphological specialization. J Comp Neurol. 403:5-32. PMID: 10075440


Reviews (1995-2014)

Krubitzer L and Stolzenberg DS (2014) The evolutionary masquerade: Genetic and epigenetic contributions to the neocortex. Curr Opin Neurobiol. 24C:157-165 PMID: 24492091

Krubitzer L and Dooley JC (2013) Cortical plasticity within and across lifetimes: How can development inform us about phenotypic transformation? Front Hum Neurosci. 7:620. PMCID: PMC3793242

Hedges JH, Adolph KE, Bavelier D, Fiez JA, Krubitzer L, McAuley JD, Newcombe NS, Fitzpatrick SM, Ghajar J (2013) Play, attention and learning: How do play and timing shape the development of attention and influence classroom learning? Ann NY Acad Sci. 1292:1-20. PMCID: PMC3842829

Krubitzer L, and Seelke AMH (2012) Cortical evolution in mammals: The bane and beauty of phenotypic variability. Proc Natl Acad Sci U S A. 109:10647-10654. PMCID: PMC3386882

Krubitzer, L, Campi KL, Cooke DF (2011) All rodents are not the same: A modern synthesis of cortical organization. Brain Behav and Evol. 78:51-93. PMCID: PMC3182045

Krubitzer, L (2009) In search of a unifying theory of complex brain evolution. The Year In Cognitive Neuroscience. Ann N Y Acad Sci. 1156: 44-67. PMCID: PMC2666944 *Link to revised Figure 7

Larsen DD and Krubitzer L (2008) Genetic and epigenetic contributions to the cortical phenotype in mammals. Brain Res Bull. 75:391-397. PMCID: PMC2607039

Krubitzer, L (2007). The magnificent compromise: Cortical field evolution in mammals. Neuron. 56:201-208. PMID: 17964240

Karlen, SJ and Krubitzer, L (2007) The functional and anatomical organization of marsupial neocortex; evidence for parallel evolution in mammals. Prog Neurobiol. 82:122-141. PMCID: PMC1978492

Krubitzer, L and Kaas, JH (2005) The evolution of the neocortex in mammals: How is phenotypic diversity generated? Curr Opin Neurobiol. 15:444-453. PMID: 16026978

Krubitzer, L and Kahn, D (2003) Nature versus nurture revisited: An old idea with a new twist. Prog in Neurobiol. 70:33-52. PMID: 12927333

Krubitzer, L and Huffman KJ. (2000) Arealization in the neocortex of mammals: Genetic and epigenetic contributions to the phenotype. Brain Behav Evol. 55:322-335. PMID: 10971017

Rosa, MG and Krubitzer, LA (1999) The evolution of visual cortex: Where is V2? Trends Neurosci. 22: 242-247. PMID: 10354599

Krubitzer, L (1998) What can monotremes tell us about brain evolution? Philos Trans R Soc Lond B Biol Sci. 353:1127-1146. PMCID: PMC1692304

Krubitzer, L (1995) The organization of neocortex in mammals: Are species differences really so different? Trends Neurosci. 18:408-417. PMID: 7482807


Book Chapters
Krubitzer L (2014) Lessons from Evolution. In: The Future of the Brain; Essays by the World's Leading Neuroscientists. (Marcus, G and Freeman, J eds). Princeton University Press pp 186 - 193.

Cooke, DF, Goldring, A, Recanzone, GH, Krubitzer, L (2014) The evolution of parietal areas associated with visuomanual behavior: From grasping to tool use. In: The New Visual Neurosciences (Chalupa, L and Werner J eds). Cambridge, MA: MIT Press, pp 1049 - 1063.

Krubitzer LA and Seelke AMH (2013) Cortical evolution in mammals: The bane and beauty of phenotypic variability. In: In the Light of Evolution. (Striedter, GF, Avise JC, and Ayala FJ eds.) National Academies Press. Chapter 6, pp. 91 – 111

Krubitzer, L., Disbrow E (2010)  The evolution of parietal areas involved in hand use in primates.  In:  Spatial Cognition, Spatial Perception.  (Dolins, EL and Mitchell, RW eds).  Cambridge University Press.  Chapter 16. Pp. 365-421.

Karlen, S.J., Hunt, D., and Krubitzer (2009).  Cross-modal plasticity in mammalian neocortex. In: Oxford Handbook of Developmental Behavioral Neuroscience: Epigenetics, Evolution, & Behavior.  Ed. Mark S. Blumberg, John H. Freeman, and Scott R. Robinson.  Oxford University Press, Inc, pp. 357-374.

Krubitzer, L. Padberg, J. (2009) Evolution of association pallial areas: parietal association areas in mammals.  In: Encyclopedic Reference of Neuroscience (Ann Butler, ed.)  Springer. Volume 5, pp 1225-1231

Karlen SJ and Krubitzer L (2009). Marsupial Neocortex. In: Squire LR (ed), Encyclopedia of Neuroscience. Oxford: Academic Press. Volume 5, pp. 671-679.

Krubitzer L and Campi K (2009). Neocortical Organization in Monotremes. In: Squire LR (ed.), Encylopedia of Neuroscience. Oxford: Academic Press. Volume 6, pp. 51-59.

.Krubitzer, L., and Disbrow, E. (2008) The evolution of parietal areas involved in hand use in primates. In:  The Senses:  A Comprehensive Reference. Volume 6, Somatosensation  (Jon Kaas and Ester Gardner eds.) Elsevier, London, pp. 183-214.

Krubitzer, L. and Hunt, D. (2007) Captured in the net of space and time: Understanding cortical field evolution. In: The Evolution of Nervous systems in mammals, Volume IV (Kaas, J.H. and Krubitzer L., eds). Academic Press, Oxford, pp. 49-72.

Disbrow, E., Hinkley, L., Padberg, J., and Krubitzer, L. Hand use and the evolution of posterior parietal cortex in primates. In: The Evolution of Nervous systems in mammals, Volume IV (Kaas, J.H. and Preuss, T. eds). Academic Press, Oxford, pp. 407-416.

Karlen, S.J. and Krubitzer, L. (2006). The evolution of the neocortex in mammals: intrinsic and extrinsic contributions to the cortical phenotype. Novartis Foundation Symposium, 270:146-169; discussion 159-163.

Krubitzer, L., and Disbrow, E. (2004). In search of self:  The evolution of parietal areas involved in hand use. In:  Spatial Perception. Cambridge University Press. Submitted.

Krubitzer, L. and Kahn, D (2004).  The evolution of human neocortex:  Is the human brain fundamentally different than that of other mammals?  In:  Attention and Performance XX, Functional Brain Imaging of Visual Cognition. (N. Kanwisher, J. Duncan, C. Umilta eds.).

Krubitzer, L.A. (2002). Evolutionary Perspectives in: Cognitive Neuroscience (M. Gazzaniga, R. Ivry, and R. Mangun eds.) W. W. Norton and Company. pp. 577-596.

Krubitzer, L.A. (2000). How does evolution build a complex brain? In: Evolutionary Developmental Biology of the Cerebral Cortex (G.R. Bock, G. Cardew, ed.) John Wiley and Sons, LTD. Chichester. pp. 206-220.

Krubitzer, L.A. (1998). Constructing the neocortex: Influences on the pattern of organization in mammals. In: Brain and Mind: Evolutionary Perspectives. (M. S. Gazzaniga and J. Altman, eds.) Human Frontier Science Program. Strasbourg, pp. 19-34.

Krubitzer, L.A. (1996). The Organization of Lateral Somatosensory Areas In Primates and Other Mammals. In: Somesthesis and the Neurobiology of the Somatosensory Cortex, International Symposium Series, (O. Franzen, R. Johanson, and L. Terenius, eds.) Boston, Birkhaeuser. pp.173-185.

Krubitzer, L., R. Belew, C. Boake, E. Boncinelli, E. Brenowitz, S. de Belle, J. Edwards, W.P.M. Geraerts. B. Kyriacou, G. Miklos, F. von Schilcher (1994). How Do Evolution and Behavior Interact? In: Dahlem Workshop on Flexibility and Constraint in Behavioral Systems. John Wiley and Sons, Chichester, pp. 295-305.

Kaas, J.H. and L.A. Krubitzer (1991). The organization of extrastriate visual cortex. (B. Dreher and S.R. Robinson, eds.), In: Vision and Visual Dysfunction, Volume 3, Neuroanatomy of the Visual Pathways and Their Development. Macmillan Press, London, pp 302-323.

Updated March 2014  ♦  Copyright 2014 Leah Krubitzer